February 7, 2018
- ヤンセンはテラバンス バイオファーマと提携して炎症性腸疾患（IBD）を標的疾患とする経口・汎JAK阻害薬を開発する。
Horsham, Pa., February 7, 2018 ― The Janssen Pharmaceutical Companies of Johnson & Johnson announced today their entry into a worldwide collaboration with an affiliate of Theravance Biopharma, Inc. to develop TD-1473, a first-in-class oral, gastrointestinal (GI) restricted pan-Janus kinase (JAK) inhibitor for the treatment of inflammatory bowel disease (IBD), which includes Crohn’s disease and ulcerative colitis (UC).
Under the terms of the agreement, Theravance Biopharma will complete a Phase 2 study in Crohn’s disease and a Phase 2b/3 induction and maintenance study in UC, planned to start in 2018. Following availability of Phase 2 data from both studies, Janssen Biotech, Inc. (Janssen) may elect to enter into an exclusive license arrangement for the program and would then assume a lead role in the subsequent development of TD-1473 in Crohn’s disease. Theravance Biopharma will continue to conduct TD-1473 development in UC through the conclusion of the Phase 2b/3 program. If TD-1473 is commercialized, Theravance Biopharma has the option to co-commercialize in the U.S., and Janssen would have sole commercialization responsibilities outside the U.S. As part of the agreement, Theravance Biopharma will receive an upfront payment and will be eligible to receive additional amounts if Janssen elects to remain in the collaboration following the completion of the Phase 2 activities.
